Recent advances in primary immunodeficiency: from molecular diagnosis to treatment.
The technological advances in diagnostics and therapy of primary immunodeficiency are progressing at a fast pace. This review examines recent developments in the field of inborn errors of immunity, from their definition to their treatment. We will summarize the challenges posed by the growth of next-generation sequencing in the clinical setting, touch briefly on the expansion of the concept of inborn errors of immunity beyond the classic immune system realm, and finally review current developments in targeted therapies, stem cell transplantation, and gene therapy.
Copyright: © 2020 Bucciol G and Meyts I.
Overview publication
| Title | Recent advances in primary immunodeficiency: from molecular diagnosis to treatment. |
| Date | 2020-01-01 |
| Issue name | F1000Research |
| Issue number | v9 |
| DOI | 10.12688/f1000research.21553.1 |
| PubMed | 32226610 |
| Authors | |
| Keywords | hematopoietic stem cell transplantation, inborn error of immunity, next generation sequencing, primary immunodeficiency, targeted therapy |
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