Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

(Science (New York, N.Y.), v370.6515)

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

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Title	Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Date	2020-10-23
Issue name	Science (New York, N.Y.)
Issue number	v370.6515
DOI	10.1126/science.abd4585
PubMed	32972996
Authors	Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC & Casanova JL
Info	Arias AA, Boisson B, Boucherit S, Bustamante J, Chbihi M, Chen J, Chrabieh M, Kochetkov T, Le Voyer T, Liu D, Nemirovskaya Y, Ogishi M, Papandrea D, Patissier C, Rapaport F, Roynard M, Vladikine N, Woollett M, Zhang P, Kashyap A, Ding L, Bosticardo M, Wang Q, Ochoa S, Liu H, Chauvin SD, Stack M, Koroleva G, Bansal N, Dalgard CL, Snow AL, Abad J, Aguilera-Albesa S, Akcan OM, Darazam IA, Aldave JC, Ramos MA, Nadji SA, Alkan G, Allardet-Servent J, Allende LM, Alsina L, Alyanakian MA, Amador-Borrero B, Amoura Z, Antolí A, Arslan S, Assant S, Auguet T, Azot A, Bajolle F, Baldolli A, Ballester M, Feldman HB, Barrou B, Beurton A, Bilbao A, Blanchard-Rohner G, Blanco I, Blandinières A, Blazquez-Gamero D, Bloomfield M, Bolivar-Prados M, Borie R, Bousfiha AA, Bouvattier C, Boyarchuk O, Bueno MRP, Bustamante J, Cáceres Agra JJ, Calimli S, Capra R, Carrabba M, Casasnovas C, Caseris M, Castelle M, Castelli F, de Vera MC, Castro MV, Catherinot E, Chalumeau M, Charbit B, Cheng MP, Clavé P, Clotet B, Codina A, Colkesen F, Colkesen F, Colobran R, Comarmond C, Corsico AG, Dalmau D, Darley DR, Dauby N, Dauger S, de Pontual L, Dehban A, Delplancq G, Demoule A, Di Sabatino A, Diehl JL, Dobbelaere S, Durand S, Eldars W, Elgamal M, Elnagdy MH, Emiroglu M, Erdeniz EH, Aytekin SE, Euvrard R, Evcen R, Fabio G, Faivre L, Falck A, Fartoukh M, Faure M, Arquero MF, Flores C, Francois B, Fumadó V, Fusco F, Solis BG, Gaussem P, Gil-Herrera J, Gilardin L, Alarcon MG, Girona-Alarcón M, Goffard JC, Gok F, González-Montelongo R, Guerder A, Gul Y, Guner SN, Gut M, Hadjadj J, Haerynck F, Halwani R, Hammarström L, Hatipoglu N, Hernandez-Brito E, Holanda-Peña MS, Horcajada JP, Hraiech S, Humbert L, Iglesias AD, Íñigo-Campos A, Jamme M, Arranz MJ, Jordan I, Kanat F, Kapakli H, Kara I, Karbuz A, Yasar KK, Keles S, Demirkol YK, Klocperk A, Król ZJ, Kuentz P, Kwan YWM, Lagier JC, Lau YL, Le Bourgeois F, Leo YS, Lopez RL, Leung D, Levin M, Levy M, Lévy R, Li Z, Linglart A, Lorenzo-Salazar JM, Louapre C, Lubetzki C, Luyt CE, Lye DC, Mansouri D, Marjani M, Pereira JM, Martin A, Pueyo DM, Martinez-Picado J, Marzana I, Mathian A, Matos LRB, Matthews GV, Mayaux J, Mège JL, Melki I, Meritet JF, Metin O, Meyts I, Mezidi M, Migeotte I, Millereux M, Mirault T, Mircher C, Mirsaeidi M, Melián AM, Martinez AM, Morange P, Mordacq C, Morelle G, Mouly S, Muñoz-Barrera A, Nafati C, Neves JF, Ng LFP, Medina YN, Cuadros EN, Ocejo-Vinyals JG, Orbak Z, Oualha M, Özçelik T, Hammarström QP, Parizot C, Pascreau T, Paz-Artal E, de Diego RP, Philippe A, Philippot Q, Planas-Serra L, Ploin D, Poissy J, Poncelet G, Pouletty M, Quentric P, Raoult D, Rebillat AS, Reisli I, Ricart P, Richard JC, Rivet N, Rivière JG, Blanch GR, Rodrigo C, Rodriguez-Gallego C, Rodríguez-Palmero A, Romero CS, Rothenbuhler A, Rozenberg F, Ruiz Del Prado MY, Riera JS, Sanchez O, Sánchez-Ramón S, Schluter A, Schmidt M, Schweitzer CE, Scolari F, Sediva A, Seijo LM, Sene D, Senoglu S, Seppänen MRJ, Ilovich AS, Shahrooei M, Smadja D, Sobh A, Moreno XS, Solé-Violán J, Soler C, Soler-Palacín P, Stepanovskiy Y, Stoclin A, Taccone F, Tandjaoui-Lambiotte Y, Taupin JL, Tavernier SJ, Terrier B, Thumerelle C, Tomasoni G, Toubiana J, Alvarez JT, Trouillet-Assant S, Troya J, Tucci A, Ursini MV, Uzunhan Y, Vabres P, Valencia-Ramos J, Van Den Rym AM, Vandernoot I, Vatansev H, Vélez-Santamaria V, Viel S, Vilain C, Vilaire ME, Vincent A, Voiriot G, Vuotto F, Yosunkaya A, Young BE, Yucel F, Zannad F, Zatz M, Belot A, Foti G, Bellani G, Citerio G, Contro E, Pesci A, Valsecchi MG, Cazzaniga M, Bole-Feysot C, Lyonnet S, Masson C, Nitschke P, Pouliet A, Schmitt Y, Tores F, Zarhrate M, Abel L, Andrejak C, Angoulvant F, Bachelet D, Basmaci R, Behillil S, Beluze M, Benkerrou D, Bhavsar K, Bompart F, Bouadma L, Bouscambert M, Caralp M, Cervantes-Gonzalez M, Chair A, Coelho A, Couffignal C, Couffin-Cadiergues S, D'ortenzio E, Da Silveira C, Debray MP, Deplanque D, Descamps D, Desvallées M, Diallo A, Diouf A, Dorival C, Dubos F, Duval X, 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B, Geijtenbeek T, Girbes A, Goorhuis B, Grobusch MP, Hafkamp F, Hagens L, Hamann J, Harris V, Hemke R, Hermans SM, Heunks L, Hollmann MW, Horn J, Hovius JW, de Jong MD, Koning R, van Mourik N, Nellen J, Paulus F, Peters E, van der Poll T, Preckel B, Prins JM, Raasveld J, Reijnders T, Schinkel M, Schultz MJ, Schuurman A, Sigaloff K, Smit M, Stijnis CS, Stilma W, Teunissen C, Thoral P, Tsonas A, van der Valk M, Veelo D, Vlaar APJ, de Vries H, van Vugt M, Wiersinga WJ, Wouters D, Zwinderman AHK, van de Beek D, Abel L, Aiuti A, Al Muhsen S, Al-Mulla F, Anderson MS, Arias AA, Feldman HB, Bogunovic D, Bolze A, Bondarenko A, Bousfiha AA, Brodin P, Bryceson Y, Bustamante CD, Butte M, Casari G, Chakravorty S, Christodoulou J, Cirulli E, Condino-Neto A, Cooper MA, Dalgard CL, DeRisi JL, Desai M, Drolet BA, Espinosa S, Fellay J, Flores C, Franco JL, Gregersen PK, Haerynck F, Hagin D, Halwani R, Heath J, Henrickson SE, Hsieh E, Imai K, Itan Y, Karamitros T, Kisand K, Ku CL, Lau YL, Ling Y, Lucas 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