The Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family.

Mohamad et al. (2020) describe loss-of-function mutations in SERPINA12 as a cause of diffuse, transgradient palmoplantar keratoderma (PPK). This disorder shares similar clinical features with other PPKs caused by protease overactivity, including erythema, peeling, and exacerbation on water exposure. Understanding this disorder may shed further light on the role of proteases and their inhibitors in epidermal physiology.

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

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TitleThe Proteolytic Network in Palmoplantar Keratoderma: SERPINA12 Joins the Family.
Date2020-11-01
Issue nameThe Journal of investigative dermatology
Issue numberv140.11:2111-2113
DOI10.1016/j.jid.2020.06.031
PubMed33099397
AuthorsSteele L, Tawfik SS & O'Toole EA
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