COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI - the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases.
Objective
There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared.
Methods
A national multicentric prospective cohort study was conducted from the French Rheumatic and Musculoskeletal Diseases (RMD) COVID-19 cohort. Patients with SAID were matched with patients with non-SAID on age±7 years, gender and number of comorbidities to consider important confounding factors. Impact of SAID on severity of SARS-CoV-2 infection was analysed using multinomial logistic regression for severity in three classes (mild, moderate and severe with mild status as reference). Fine-Gray regression model for length of hospital stay and binomial logistic regression model for risk of death at 30 days.
Results
We identified 117 patients with SAID (sex ratio 0.84, 17 children) and compared them with 1545 patients with non-autoinflammatory immune-mediated inflammatory disorders (non-SAID). 67 patients had a monogenic SAID (64 with familial Mediterranean fever). Other SAIDs were Behçet' disease (n=21), undifferentiated SAID (n=16), adult-onset Still disease (n=9) and systemic-onset juvenile idiopathic arthritis (n=5). Ten adults developed severe form (8.6%). Six patients died. All children had a benign disease. After matching on age±7 years, sex and number of comorbidities, no significant difference between the two groups in length of stay and the severity of infection was noted.
Conclusion
As identified in the whole French RMD COVID-19 cohort, patients with SAID on corticosteroids and with multiple comorbidities are prone to develop more severe COVID-19 forms.
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Overview publication
Title | COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI - the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases. |
Date | 2022-05-01 |
Issue name | RMD open |
Issue number | v8.1 |
DOI | 10.1136/rmdopen-2021-002063 |
PubMed | 35537796 |
Authors | |
Info | FAI2R/SFR/SNFMI/SOFREMIP/CRI/IMIDIATE consortium and contributors, Aeschlimann F, Agard C, Ait-Abdallah N, Albert JD, Alcaix D, Allain JS, Allanore Y, Amoura Z, Amouzougan A, Andre E, Arbault A, Arlet JB, Arnaud L, Arniaud D, Arty-Hue H, Atlan L, Tours AA, Audoin-Pajot C, Audren V, Avenel G, Avouac J, Bach-Bunner M, Bacquet-Deschryver H, Bader-Meunier B, Balandraud N, Balblanc JC, Ballot-Schmit C, Bally S, Banal F, Banneville B, Barbery P, Barrelet A, Bart G, Basch A, Baumier V, Bayer G, Bayle S, Beauvais C, Beinat R, Belin V, Belkhir R, Belot A, Beltai A, Benainous R, Benammar M, Bendahmane C, Benhamou M, Benhamou Y, Benmansour A, Bennet P, Bernoux-Manat B, Berthet E, Berthier S, Berthoud O, Berthoux E, Bertolini E, Bigot A, Bisson-Vaivre A, Blaison G, Bolla G, Bonidan O, Bonnet C, Borie R, Borocco C, Bossert M, Boudou L, Bouhour F, Bouiller K, Bouillet L, Bouldoires B, Bourree T, Boussen I, Boussoualim K, Bouvard E, Regine B, Buchlin P, Cabantous L, Cacoub P, Cadiou S, Cantagrel A, Caplanne D, Carbasse A, Carteni M, Castel B, Cathebras P, Caumont H, Cayot-Bouillet A, Celant A, Chaffin A, Chaigne B, Chaillous B, Champy R, Charcot A, Charles P, Charlot-Lambrecht I, Charpin C, Chatelus E, Chaudier B, Chazerain P, Chertok P, Chevalier X, Chevreau M, Chotard E, Bertolini E, Bigot A, Bisson-Vaivre A, Blaison G, Bolla G, Bonidan O, Bonnet C, Borie R, Borocco C, Bossert M, Boudou L, Bouhour F, Bouiller K, Bouillet L, Bouldoires B, Bourree T, Boussen I, Boussoualim K, Bouvard E, Regine B, Buchlin P, Cabantous L, Cacoub P, Cadiou S, Cantagrel A, Caplanne D, Carbasse A, Carteni M, Castel B, Cathebras P, Caumont H, Cayot-Bouillet A, Celant A, Chaffin A, Chaigne B, Chaillous B, Champy R, Charcot A, Charles P, Charlot-Lambrecht I, Charpin C, Chatelus E, Chaudier B, Chazerain P, Chertok P, Chevalier X, Chevreau M, Chotard E, Lin DCM, Claudepierre P, Clavel G, Clavel-Osorio C, Clay M, Clet J, Cohen F, Cohen G, Colette-Cedoz ME, Collercandy N, Colombey A, Comarmond C, Combe B, Comparon C, Constant E, Constantin A, Coquerelle P, Corli J, Corre C, Costedoat-Chalumeau N, Couderc M, Couret M, Coury-Lucas F, Coutarel C, Coutier F, Damade R, Daver-Malaterre L, Moreuil C, Decrock M, Delahousse M, Barrois ED, Deligny C, Denarie D, Denis A, Deprouw C, Dernis E, Deroux A, Desbarbieux R, Descamps E, Desdoits A, Deslandre C, Desmurs M, Despaux J, Desplats M, Detree F, Devauchelle-Pensec V, Devaux M, Dhote R, Diaz H, Dieude P, Dieudonne Y, Diot E, Direz G, Djeddi DD, Domont F, Douvier S, Drouet B, Dubost JJ, Duc C, Ducornet A, Dufauret-Lombard C, Dumaine C, Dumel AE, Dumoulin-Richez C, Duquesne A, Durand G, Durandin-Truffinet M, Duret PM, Durieux-Mehlman S, Dusser-Benesty P, Duval M, Ebbo M, Ebstein E, Economu-Dubosc A, Mahou SE, Emilie S, Euvrard R, Evon P, Eymard-Gibert C, Fabre S, Fagedet D, Farge-Bancel D, Farhat M, Fauconier M, Fautrel B, Echtenbaum J, Felten R, Ferreira-Maldent N, Feurer E, Fichet A, Flaisler F, Flipo RM, Florens N, Foltz V, Fontanges E, Foret J, Fougerousse AC, Fouque-Aubert A, Foutrier-Morello C, Francois-Pradier H, Frantzen L, Fremond ML, Fritz P, Froissart A, Fulpin J, Gaches FF, Gagneux-Lemoussu L, Penhoat MG, Galland J, Gandjbakhch F, Gardette A, Garnier N, Garraud T, Garrot JF, Gastaldi R, Gaudin P, Gaud-Listrat V, Gauthier-Prieur M, Gauzere L, Georgescu D, Georgin-Lavialle S, Gerard N, Gervais E, Gibert C, Gibert E, Gill G, Gillard J, Gilson M, Gimonnet P, Quintrec JG, Giraud-Morelet A, Glace B, Glanowski C, Godeau B, Gombert B, Gonnet-Gracia C, Goulenok T, Goupille P, Gourmelen O, Govindaraju-Audouard S, Grados F, Grall-Lerosey M, Grardel B, Grasland A, Grateau G, Groza M, Guggenbuhl P, Guichard I, Guillaud C, Guillaume-Czitrom S, Guillibert C, Guillot X, Guilpain P, Gury A, Guyader P, Guyot MH, Hachulla E, Hacquard-Bouder C, Havard MN, Hellier JP, Hennequin P, Henriot B, Henry J, Hentgen V, Hermet M, Hernandez J, Hie M, Hilliquin P, Hinschberger O, Hittinger-Roux A, Holubar J, Shing Koy EH, Hua C, Hudry C, Huguenel S, Jaccard C, Jacquemier JM, Jamard B, Jan C, Jean S, Joffres L, Jousse-Joulin S, Jouvray M, Juge PA, Juillard L, Jullien D, Kabchou A, Karkowski L, Karman F, Kemiche F, Keraen J, Kieffer P, Kone-Paut I, Koreichi A, Kostine M, Krebs S, Alanore SB, Lacombe V, Lafforgue P, Lahalle S, Lambert M, Lambrecht I, Lamer F, Langlois V, Lanot S, Lanteri A, Larbre JP, Latourte A, Lavigne C, Gouellec NL, Guegan SLG, Guenno GL, Lebrun A, Ledoult E, Legoupil N, Legrand E, Leguy D, Leloire O, Leroux C, Leroy R, Leroy-Gouix M, Leske C, Leturcq T, Leurs A, Michaud CL, Limbach FX, Liote F, Lohse A, Lozac'h P, Lucas C, Mabrut E, Madelon A, Magy-Bertrand N, Mahevas M, Maillard H, Maillet T, Maillot F, Malochet-Guinamand S, Mangon Q, Mankikian J, Marchou Lopez S, Margarit N, Marhadour T, Maria A, Mariette X, Marotte H, Martin C, Martin T, Mathian A, Maurier F, Maury F, Mazet-Guillaume B, Mazouyez A, Mazyad H, Mehsen-Cetre N, Mekinian A, Melki I, Meric JC, Messer L, Michaud M, Michel C, Michel M, Michon M, Milesi-Lecat AM, Molto A, Moranne O, Morel G, Morel H, Morel J, Morin F, Moulinier L, Moulis G, Moura B, Naude C, Nguyen M, Nicolas-Vullierme S, Nielly H, Nocturne G, Nottez A, Ollagnon HO, Oziol E, Pacaud-Vitoux I, Padern G, Pagnier A, Paris C, Parrot A, Pascart T, Pascaud-Mansour Y, Paulin L, Pavy S, Payet J, Perard L, Pereira-Gillion C, Pers YM, Pertuiset E, Pha M, Pham T, Pichon M, Pierreisnard A, Pizana G, Poignant S, Poix E, Portier A, Pouchot J, Poulet A, Poursac N, Pugnet G, Puyraimond-Zemmour D, Quartier-Dit-Maire P, Marion Q, Queyrel V, Raffray L, Razanamahery J, Remy P, Renard M, Rene J, Revuz S, Rey B, Richard-Colmant G, Richer O, Richez C, Riviere E, Riviere E, Riviere S, Robin S, Rohmer J, Roitg I, Rolland M, Roriz M, Rosenberg C, Rossi L, Roth O, Rouidi SA, Roumier M, Rousiere M, Ousselin C, Rouviere B, Roux C, Roux F, Roux M, Roux N, Rouzaud D, Rozenberg S, Adeline RW, Isabelle S, Fatiha S, Sailler L, Salliot C, Salmon JH, Samaille C, Samson M, Saraux A, Savey L, Schmidt J, Seguier J, Sellam J, Senbel E, Sene T, Senet P, Seror R, Servettaz A, Seve P, Sicaud A, Sivova N, Sobanski SV, Sordet C, Sornay-Rendu E, Soubrier M, Souchaud-Debouverie O, Sourisseau-Diverres G, Sparsa L, Spielmann L, Stavris C, Steib S, Straus C, Strotz V, Mathieu S, Taffignon-Clave S, Talmud D, Taraud C, Tenenbaum N, Theillac C, Thomachot, Thomas T, Tieulie N, Tiriau S, Tison A, Tournadre A, Toussirot E, Trefond L, Trijau S, Trouillier S, Trouvin AP, Truchetet ME, Uettwiller F, Ulrich F, Uzunhan Y, Valls-Bellec I, Vaquier J, Veillard E, Veillon L, Vial G, Viallard JF, Victor J, Vidon C, Vigne VC, Virone A, Warzocha U, Wendling D, Werle C, Wibaux C, Wisniewski M, Woessner J, Xerri-Campano B |
Keywords | COVID-19, autoimmune diseases, biological therapy, familial Mediterranean fever |
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