HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19.
We analyzed the association between HLA polymorphisms and susceptibility to SARS-CoV-2 infection and disease severity. Genotyping data from a total of 9373 COVID-19-positive cases from the Spanish Coalition to Unlock Research on Host Genetics on COVID-19 (SCOURGE) consortium and 5943 population controls were included in the study. We found an association of the alleles HLA-B*14:02 and HLA-C*08:02 with a lower risk to COVID-19 infection (p = 0.006, OR = 0.84, 95% CI = [0.75-0.95], p = 0.024, OR = 0.86, 95% CI = [0.78-0.95], respectively). We also found the alleles HLA-A*11:01 and HLA-C*04:01 associated with disease severity (p = 0.033, OR = 1.16, 95% CI = [1.04-1.31], p = 0.045, OR = 1.14, 95% CI = [1.05-1.25], respectively). These results suggest that an effective presentation of viral peptides by HLA class I alleles involve a faster infection clearance, decreasing the susceptibility and severity of COVID-19.
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Overview publication
| Title | HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19. |
| Date | 2023-12-01 |
| Issue name | HLA |
| Issue number | v102.6:731-739 |
| DOI | 10.1111/tan.15160 |
| PubMed | 37528566 |
| Authors | |
| Info | Scourge Cohort Group, Abellan J, Acosta-Isaac R, Aguado JM, Aguilar C, Aguilera-Albesa S, Sabbagh AA, Alba J, Albu S, Alcalá-Gallardo KAM, Alcoba-Florez J, Batres SA, Algarin-Lara HR, Almadana V, Almeida J, Almoguera B, Alonso MR, Alvarez N, Álvarez-Benítez Y, Álvarez-Navia F, Walther RA, Andreu-Bernabeu Á, Antonijoan MR, Arana-Arri E, Aranda C, Arango C, Araque C, Araujo NK, Araujo IMT, Arcanjo AC, Arnaiz A, Fernández FA, Arranz MJ, Lopez JRA, Artiga MJ, Avello-Malaver Y, Ayuso C, Baldion AM, Martín BB, Baptista-Rosas RC, Barranco-Díaz A, Barreda-Sánchez M, Barrera-Penagos V, Belhassen-Garcia M, Bernal E, Bernal-Bello D, Bezerra JF, Bezerra MAC, Blanca-López N, Blancas R, Boix-Palop L, Borobia A, Bravo E, Brion M, Brochado-Kith Ó, Brugada R, Bustos M, Cabello A, Caceres-Agra JJ, Calbo E, Calderón EJ, Camacho S, Campos MC, Cañadas Y, Carbonell C, Cardona-Huerta S, Carioca AAF, Carpintero MS, Segura CC, Carratto TMT, Carrillo-Avila JA, Carvalho MCC, Casasnovas C, Castano L, Castaño CF, Castelao JE, Candalija AC, Castillo MA, Ceballos FC, Chaux JG, Chaves-Santiago WG, Chiquillo-Gómez S, Cid-Lopez MA, Cienfuegos-Jimenez O, Conde-Vicente R, Cordero-Lorenzana ML, Corella D, Corrales A, Cortes-Sanchez JL, Corton M, Costa TX, Cruz R, Cruz MS, Cuesta L, Cunha GCR, da Silva GV, Dalmau D, Dantas-Komatsu RCS, Darnaude MT, de Andrés R, de Araújo JNG, de Juan C, De la Cruz Troca J, de la Horra C, de la Hoz AB, De Martino-Rodríguez A, de Sousa Alves Neri JL, Del Campo-Pérez V, Delgado-Cuesta J, Diaz-Caneja CM, Díaz-Pérez A, de Bustamante AD, Dietl B, Almeida SD, do Monte Alves M, Domínguez-Garrido E, Dos Santos KA, Duarte AM, Echave-Sustaeta J, Eiros R, Enciso-Olivera CO, Escudero G, España PP, Sanabria GME, Fariñas MC, Fernandes MR, Fernández R, Fernandez-Caballero L, Fernández-Cruz A, Fernandez-Nestosa MJ, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Sampedro M, Fernández-Sánchez R, Fernández-Villa T, Ferrero SF, Martínez YF, Capitán CF, Flores-Pérez P, Friaza V, Fuenmayor-Hernández L, Núñez MF, Fumadó V, Gadea I, Gagliardi L, Gago-Domínguez M, Gallego N, Galoppo C, García I, García M, García L, Garcia-Cerrada C, García-de-Vicuña A, Garcia-García J, García-García I, García-Ibarbia C, García-Montero AC, García-Soidán A, García-Vázquez E, Torrejón MCG, Garza-Frias E, Gentile A, Gil-Fournier B, Gómez-Arrue J, Gómez-Duque M, Carrera LG, García MG, Sacristán ÁG, González-Neira A, González-Peñas J, Gonzalez-Sagrado M, Álvarez BG, de Quirós FGB, Benito HG, Gorgojo-Galindo O, Górgolas M, Guaragna F, Guegel GP, Guillen-Guio B, Guillen-Navarro E, Guisado-Vasco P, Gutiérrez-Bautista JF, Gutierrez-Castañeda LD, Heili-Frades S, Hernandez E, Hernandez-Ortega LD, Hernández-Pérez G, Hernández-Vaquero R, Moro CH, Herraez B, Herranz MT, Herrera M, Herrero MJ, Herrero-Gonzalez A, Horcajada JP, Imaz-Ayo N, Intxausti-Urrutibeaskoa M, Íñiguez M, Jacomo RH, Jara R, Jazmin PM, Jiménez Á, Jiménez P, Jiménez-Alfaro I, Jimenez-Sousa MA, Jordan I, Laguna-Goya R, Laorden D, Lasa-Lazaro M, Lattig MC, Lauriente A, Borja AL, Llanos L, López-Bernús A, Lopez-Garcia E, Lopez-Rodriguez R, López-Ruz MA, Granados EL, Lorente L, Lozano JE, Lozano-Espinosa M, Luchessi AD, Mahillo I, Mancebo E, Mar C, Calvo CM, Marcos M, Marcos-Delgado A, Candon AM, Aguilar PM, Martín MM, Martín MD, Martín V, Martin-Fernandez M, Martín-López C, Martín-Oterino JÁ, Martin-Pedraza L, Martín-Vicente M, Martinez A, Martínez R, Martínez JJ, Martínez S, Martínez-Aquino E, Martínez-González Ó, Martinez-Lopez I, Martinez-Nieto O, Martinez-Paz P, Martinez-Perez A, Martínez-Ramas A, Martinez-Resendez MF, Robles VM, Marzal L, Mazzeu JF, Medeiros JFP, Medeiros KA, Medrano FJ, Meijome XM, Mejuto-Montero N, Méndez-Echevarria A, Charris HM, Macías EM, Mercadillo F, Mercado-Sesma AR, Minguez P, Molina AJJ, Molina-Roldán E, Montoya JJ, Moraes VMS, Moreira-Escriche P, Morelos-Arnedo X, Moreno-Docón A, Moreno-Escalante J, Cuerda VM, Fernández AM, Morilla R, García PM, Neira P, Nevado J, Nieto-Gañán I, Nunes JFR, Nuñez-Torres R, Obrador-Hevia A, Ocejo-Vinyals JG, Olivar V, Oliveira SF, Ondo L, Orfao A, Ortega L, Ortega-Paino E, Ortiz-Flores F, Ortiz-Lopez R, Oteo JA, Pachajoa H, Pacheco M, Pacheco-Miranda FJ, Conejo IP, Panadero-Fajardo S, Parellada M, Pariente-Rodríguez R, Paz-Artal E, Peces-Barba G, Pedromingo Kus MS, Perales C, Perez P, Pérez C, Perez-de-Nanclares G, Pérez-García F, Pérez-Matute P, Pérez-Serra A, Pérez-Tomás ME, Perucho T, Pichardo LA, Pinho SMT, Pinsach-Abuin M, Pinzón LA, Pita G, Pla-Junca F, Planas-Serra L, Pompa-Mera EN, Porras-Hurtado GL, Pujol A, Chávez MEQ, Quijada MA, Quintela I, Ramirez-Montaño D, León SR, Sedes PR, Recalde D, Recio-Fernández E, Resino S, Ribeiro AP, Rivadeneira-Chamorro CS, Roa-Agudelo D, Pardo MR, Rodriguez MJ, Rodriguez-Artalejo F, Rodríguez-Ferrer M, Rodriguez-Gallego C, Rodriguez-Garcia JA, Rodriguez-Hernandez MA, Rodriguez-Nicolas A, Rodriguez-Palmero A, Rodríguez-Ruiz E, Rodriguez-Urrego PA, Maya BR, Novoa GER, Rojo F, Romero-Coronado A, García FR, Rosa LS, Rosales-Castillo A, Rubio C, Olivera MR, Ruiz M, Ruiz-Cabello F, Ruiz-Casares E, Ruiz-Cubillan JJ, Ruiz-Hornillos J, Ryan P, Salamanca HD, Salazar-García L, Origlia GGS, Sánchez PL, Sánchez-Pablo C, Sánchez-Pernaute O, Sánchez López AJ, Prados MCS, Real JS, Redondo JS, Sancho-Sainz C, Sangil A, Santos A, Santos NPC, Schlüter A, Segovia S, Serra-Llovich A, Puras FS, Porras MS, Sicolo MA, Silbiger VN, Silva NS, Silva FTC, Fuentes CS, Solé-Violán J, Soria JM, Sorlí JV, Sousa RR, Souto JC, Souza KSC, Souza VS, Sprockel JJ, Suárez-Rama JJ, Suarez-Zamora DA, Taboada-Fraga X, Tamayo E, Tamayo-Velasco A, Taracido-Fernandez JC, Tavares NAC, Tellería C, Castaño JAT, Teper A, Torres-Macho J, Torres-Tobar L, Torres Gutiérrez RP, Troya J, Urioste M, Valencia-Ramos J, Valido A, Gallo JPV, Varón B, Vasconcelos RHT, Vega T, Velasco-Quirce S, Vélez-Santamaría V, Víctor V, Estévez JV, Vieitez-Santiago M, Vilches C, Villalobos L, Villar F, Villar-Garcia J, Villaverde C, Villoslada-Blanco P, Virseda-Berdices A, Yáñez Z, Zapatero-Gaviria A, Zarate R, Zazo S, de Heredia ML, Mendes I, Moreno R, Sande E, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P, Carracedo A |
| Keywords | COVID-19, HLA evolutionary divergence, HLA-A*11:01, HLA-C*04:01, SARS-CoV-2, immunogenetics |
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