Prevalence and clinical features of chronic uveitis in pediatric inflammatory bowel diseases: A nationwide study.

Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily affecting the gastrointestinal tract but capable of impacting various organs, including the eye, with uveitis being the most common ocular condition. We assessed uveitis prevalence and clinical features in a nationwide cohort of pediatric IBD. Among 4229 cases, six patients (four Crohn's disease, one ulcerative colitis, and one unclassified IBD) were identified, resulting in an overall prevalence rate of 141.8 per 100,000 patients. Uveitis onset varied: two before IBD, two after, and two concomitantly. Symptomatic uveitis occurred in 2/6 patients, with anterior involvement in all cases. Median follow-up was 3 years (interquartile range 2-4.75 years). At the last follow-up, 5/6 patients exhibited quiescent IBD, while 4/6 had inactive uveitis. One patient had ocular complications. Uveitis is a rare but potentially complicating manifestation of pediatric IBD.

© 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

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TitlePrevalence and clinical features of chronic uveitis in pediatric inflammatory bowel diseases: A nationwide study.
Date2024-06-01
Issue nameJournal of pediatric gastroenterology and nutrition
Issue numberv78.6:1305-1309
DOI10.1002/jpn3.12216
PubMed38594804
AuthorsManiscalco V, Scarallo L, Aloi M, Alvisi P, Norsa L, Zuin G, Simonini G & Lionetti P
KeywordsCrohn's disease, Extraintestinal manifestations, inflammatory bowel diseases (IBD), ulcerative colitis
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