Clinical efficacy of SARS-CoV-2 Omicron-neutralizing antibodies in immunoglobulin preparations for the treatment of agammaglobulinemia in patients with primary antibody deficiency.

(Journal of medical virology, v96.6:e29738)

Immunocompromised individuals are at significantly elevated risk for severe courses of coronavirus disease 2019 (COVID-19). In addition to vaccination, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies (nAbs) have been applied throughout the pandemic, with time of treatment onset and potency against the currently prevailing virus variant identified as relevant factors for medical benefit. Using data from the European Society for Immunodeficiencies (ESID) registry, the present study evaluated COVID-19 cases in three groups of patients with inborn errors of immunity (IEI; 981 agammaglobulinemia patients on immunoglobulin replacement therapy (IGRT); 8960 non-agammaglobulinemia patients on IGRT; 14 428 patients without IGRT), and the neutralizing capacity of 1100 immunoglobulin lots against SARS-CoV-2 ("Wuhan" and Omicron strains), throughout 3 years. From the first (2020/2021) to the second (2021/2022) cold season, i.e., during the virus drift to the more contagious Omicron variants, an increase in case numbers was recorded that was comparable (~2- to 3-fold) for all three study groups. During the same period, immunoglobulin lots showed a profound nAb increase against the archetypal SARS-CoV-2 strain, yet only low levels of Omicron nAbs. Notably, shortly before the third (2022/2023) cold season, Omicron-neutralizing capacity of released immunoglobulin lots had plateaued at high levels. From the second to the third cold season, COVID-19 cases dropped markedly. While a ~6-fold case reduction was recorded for the groups of non-agammaglobulinemia patients on IGRT and IEI patients not receiving IGRT, the decline was ~30-fold for the group of agammaglobulinemia patients on IGRT. These findings suggest a substantial COVID-19-protective effect of IGRT, at least for distinct groups of antibody-deficient patients.

© 2024 Takeda Manufacturing Austria AG and The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.

Read publication

Overview publication

TitleClinical efficacy of SARS-CoV-2 Omicron-neutralizing antibodies in immunoglobulin preparations for the treatment of agammaglobulinemia in patients with primary antibody deficiency.
Date2024-06-01
Issue nameJournal of medical virology
Issue numberv96.6:e29738
DOI10.1002/jmv.29738
PubMed38884390
AuthorsKarbiener M, Kindle G, Meyts I, Seppänen MRJ, Candotti F, Kamieniak M, Ilk R, Kreil TR & Seidel MG
InfoESID‐COVID Consortium, Abd Elaziz D, Abdelkader Sohilla LM, Abitbol A, Abolhassani H, Abrahim L, Abuzakouk M, Achir Moussouni N, Afonso V, Agyeman P, Ahlmann M, Aiuti A, Akl A, Aksu G, Albers K, Albert M, Alecsandru Meda D, Aleinikova O, Aleshkevich S, Allende L, Alligon M, Alsina AZ, de Lara Laia M, Ambrosch-Barsoumian D, Ameshofer L, Amour K, Anadol E, Ananthachagaran A, Andriamanga C, Andris J, Andritschke K, Angelini F, Ankermann T, Apel K, Arami S, Ardeniz Ö, Arkwright P, Arnold K, Ascherl R, Assam N, Assia-Batzir N, Atschekzei F, Aumann S, Aumann V, Aurivillius M, Ausserer B, Avcin T, Aydemir S, Aygören-Pürsün E, Ayvaz Deniz C, de Azevedo ACB, Azzari C, Babacar L, Bach P, Bachmann S, Bader P, Bakhtiar S, Bancé R, Bangs C, Baratault Merlin S, Barfusz K, Baris S, B BI, Bartsch M, Baumann H, Baumann U, Baumeister V, Baxendale H, Bazen S, Beaurain B, Beauté J, Beck N, Becker B, Becker C, Behrends U, Beider R, Beier R, Belke L, Bellert S, H BB, Ben Slama L, Ben-Bouzid A, Berdous-Samed T, Bergils J, Berglöf A, Bergman P, Bernatoniene J, Bernatowska E, Bernat-Sitarz K, Bernbeck B, Bethune C, Beuckmann K, Bhole M, Biegner AK, Bielack S, Bienemann K, Bigl A, Bigorgne A, Bijl M, Binder N, Bitzenhofer-Grüber M, Blanchard Rohner G, Blank D, Blattmann C, Blau J, Blaziene A, Blazina S, Blume R, Boardman B, Bode S, Boelens JJ, Boesecke C, Bogaert D, Bogner J, Bohynikova N, Booth C, Bordon V, Borkhardt A, Borte M, Borte S, Bossaller L, Bossard M, Botros J, Boucherit S, Boutros J, Boyarchuk O, Boyman O, Boztug K, Braschler T, Bravo S, Bredius R, Bright P, Brodszki N, Brodt G, Brolund A, Brosselin P, Brummel B, Brunner J, Bruns R, Brun-Schmid S, Buchta C, Buck D, Bücker A, Buckland M, Bührlen M, Burdach S, Burns S, Burton J, Caminal L, Cancrini C, Canessa C, J CA, Cantoni N, Capilna B, Caracseghi F, Caragol I, Carbone J, Carrabba M, Chamberlain L, Chantrain C, Chapel H, Chassot J, Chee R, Chinello M, Chopra C, Chovancova Z, Christmann M, Chrzanowska K, Ciznar P, Claes K, Classen Carl F, Classen M, Cochino AV, Corbacioglu S, Cordeiro Ana I, Cordier Wynar D, Core C, Costes L, Coulter T, Courteille V, Cristina M, Cucuruz M, Dabrowska Leonik N, Dähling M, Daly Mary L, Daniel CS, Danieli M, Danieli Maria G, Darroch J, Davies G, de Baets F, De Boeck C, De Gracia J, De Gracia RJ, de Nadai N, de Schutter I, De Vergnes N, de Vries E, Debert T, Debré M, Defila C, Deimel J, Delaplace D, Dellepiane Rosa M, Dellert N, Delliera L, Delor A, Demel U, Dempster J, M M DO, Dengg R, Desisa Sora A, Desta A, Detkova D, Dewerchin M, Dieli Crimi R, Dilloo D, Dimitriou F, Dinser J, Dipani N, Dirks J, Dittrich AM, Djermane L, Dogru Y, Dogu Esin F, Dombrowski A, Döring M, Drabe Camilla H, Drerup S, Drexel B, G J A D, Dückers G, Dudoit Y, Duppenthaler A, Durandy A, Ebetsberger-Dachs G, Ecser Mate B, Edgar J D, Eekman M, Ehl S, Ehrat R, Eisl E, Ekwall O, El Hawary R, Elbe S, Elcombe S, Eldash A, Eldeen Youssif ARS, El-Helou SM, P M E, Elling R, Elliott J, El-Marsafy A, Engelhardt A, Ernst D, Ersoy F, Esper S, Esteves I, Exley A, Faber M, Fabio G, Fahrni G, Faletti Laura E, Farber CM, Faria E, Farkas H, Farmaki E, Faßhauer M, Fasth A, Fätkenheuer G, Faustmann S, Fecker G, Feighery C, Feiterna-Sperling C, Fernandez-Cruz Perez E, Ferreira Concalo C, Ferster A, Feuchtinger T, Feyen O, Finke D, Fischer A, Fitter S, Flaschberger S, Fleckenstein L, Föll D, Fontana A, Forino C, Förster-Waldl E, Franchet N, Freitag D, P FU, Friedel E, Friedrich W, Frisch B, Frischknecht L, Fritzemeyer S, Gagro A, Gahr M, Gambineri E, Gamper A, Gams F, Ganzow A, Garcez T, Garcia Prat M, Gardulf A, Garibay J, Garwer B, Gasteiger L, Gathmann B, Gathmann J, Gebauer C, Geberzahn L, Geikowski T, Geisen U, Gemander C, R GA, Gerisch M, Gernert M, Gerrer K, Gerschmann S, Ghosh S, Giannini C, Gil Herrera J, Girndt M, Girrbach R, Girschick H, Gkantaras A, Gkougkourelas I, Gładysz D, Gnodtke E, Goda V, Goddard S, Goebel D, Goffard JC, Goldacker S, Gollowitsch Eva M, Gomes M, Gompels M, Gonzalez Granado Luis I, González M, Gordins P, Göschl L, Gossens L, Gößling K, Gowin E, Graafen L, Graca L, Graf D, Graf N, Grange E, Grashoff H A, Greil J, Grigoriadou S, Grimbacher B, Gronlund H, Groß-Wieltsch U, Guerra T, Guevara-Hoyer K, Guibert N, Gülnur B, Güngör T, Guseva M, Guzman D, H Haverkamp M, Haag M, Haase G, Haenicke H, Haerynck F, Hafsa I, Hagin D, Hallek M, Hammarström L, Hancioglu G, Handgretinger R, G HL, Hansen S, Hariyan T, Harrer T, Hassunah P, Hatzistilianou M, Hauck F, Hauser T, Hayman G, Heath P, Hedrich C, Heeg M, Heike M, Heimbrodt M, Heine S, Heininger U, Heinrich C, Heinz V, Heitger A, Helbert M, Helbling A, Hellige A, Hempel J, Henderson K, Henes J, Henneke P, Hennig C, Henrichs K, Herbst M, Hermann W, Hermine O, Hernández A, Hernandez M, Heropolitanska E, Herriot R, Herrmann F, Herwadkar A, Hess C, Hess U, Hesse S, Higgins S, Hilfanova A, Hilpert S, Hintze C, Hlaváčková E, Hodl I, Hodzic A, Hoernes M, Hoffmann C, Holbro A, Höllinger C, Holtsch L, Holzer U, Holzinger D, Hönig M, Hönscheid A, Horn J, Horneff G, Hoyoux C, Hristova N, Hübel K, Hübner A, Huemer C, Huissoon A, Hülsmann B, Hundsdörfer P, Huppertz HI, Huß K, Hussain S, Husson J, Hüttner-Foehlisch T, Ijspeert H, Ikinciogullari A, İlknur K, Irga N, Jablonka A, Jahnz-Rozyk K, Jakob M, Jakoby D, Jandus P, Jansson A, Jaquet M, Jardefors H, Jargulinska E, Jauk B, Jesenak M, Jilka K, Jolles S, Jones A, Jones R, Jonkman-Berk B, Jönsson G, J JH, Juliana P, Kabesch M, Kager L, Kahlert C, Kaiser-Labusch P, Kakkas I, Kamitz D, Kanariou M, Kanz L, Karakoc-Aydiner E, Karanovic B, Kartal-Kaess M, Käser E, L KT, Kayserova H, Kelleher P, Kerre T, Kilic Sara S, Kirchner M, Kiwit S, Kiykim A, Klasen J, Klaudel-Dreszler M, Klein A, Klein C, Kleine I, Kleinert S, Klein-Franke A, Klemann C, Klima M, Kobbe R, Kocacik Uygun Dilara F, Koch M, Kochler Y, Kohistani N, Kojic M, Kolios A, Kölsch U, Koltan S, Kondratenko I, Königs C, Konoplyannikova J, Kopac P, Kopp J, Körholz D, Körholz J, Korte P, Kostyuchenko L, Kötter I, Kracker S, Králícková P, Kramm C, Kramme P, Kreuz W, Kriván G, Kropshofer G, Krüger R, Krystufkova O, Ktistaki M, Kühl JS, Kühn A, W KT, Kuis W, Kullmann S, Kulozik A, Kumararatne D, Kümmler R, Kündgen A, Kurenko-Deptuch M, Kuss Paula C, Kütükcüler N, Lafoix-Mignot C, Lamers B, Lanbeck P, Landais P, Landwehr-Kenzel S, Langemeyer V, Langer T, Lankisch P, Lanz N, de Lara M, Lara-Villacanas E, Laubenthal L, Laws HJ, Leahy R, Lee JY, Lehmann A, Lehmberg K, Lehner P, Leibfrit H, Leistner L, Lesch P, Leutner S, Liatsis M, Libai Véghová L, Liebel J, G LJ, Linauskiene K, Linde R, Linßner M, Lippert Conrad F, Litzman J, Llobet P, Lodin T, Lokaj J, Longhino D, Longhurst H, Lopes DSS, Lorenzen C, Lortholary O, Lougaris V, Löw D, Lubatschofski A, Lucas M, Lutz-Wiegers V, Maaß S, Maccari Maria E, Macura-Biegun A, Maerz V, Maggina P, Mahlaoui N, Mahrenholz H, Maier S, Makhlouf M, Malfroot A, Malinauskiene L, Mannhardt-Laakmann W, Manson A, Mantkowski F, Manzey P, Marasco C, Marcus-Mandelblit N, Marg W, Markelj G, Marodi L, Marques José G, Marques L, Marschall K, Martinez de la Ossa SR, Martínez N, Martinez-Saguer I, Martire B, Marzollo A, Masekela R, Masjosthusmann K, Masmas Tania N, Matamoros N, Mattern J, Mau-Asam P, McDermott E, McIntosh N, Meglic Karmen M, Meijer R, Meinhardt A, Meshaal S, Messaoud Y, Meyer B, Meyer-Olson D, Micol R, Micoloc B, Mielke G, Mignot Loic L, Milito C, Misbah S, Mohr M, Mohrmann K, Moin M, Molinos L, Möller J, Möller-Nehring S, Morbach H, Moschese V, Moser O, Moshous D, Motkowski R, Motwani J, Mouftah Galal N, Müglich C, Mukhina A, Müller C, Muller E, Müller G, Müller H, Müller I, Müller T, Müller Z, Müller-Ladner U, Müller-Stöver S, Münstermann E, Murtra Garrell N, Muschaweck M, Mutert M, Nademi Z, Naik P, Näke A, Nalda Andrea M, Nasrullayeva G, Naumann-Bartsch N, Nemitz V, Neubauer A, Neubert J, Neumann C, Neves João F, Niehues T, Niemuth M, Nieters A, Nieuwhof C, Nolkemper D, Noorani S, Noorlander Budde A, Notheis G, Nowatsh Sanam A, Obenga G, Ocak S, Oker M, Oksenhendler E, Olbrich P, Olipra A, Omran H, Oommen P, Orosova J, Oskarsdottir S, Özsahin H, Pac M, Pachlopnik Schmid J, Pandolfi F, Papadopoulou-Alataki E, Papatriantafillou-Schmieder A, Parra-Martinez A, Paschenko O, Pašić S, Pasnik J, Patel S, Pavlík M, Paz Artal E, Peeters A, Pereira da Silva SB, Perez-Becker R, Perlhagen M, Peter HH, Pfreundschuh M, Philippet P, Picard C, Pietrucha B, Pietzsch L, Pignata C, Piquer Gibert M, Pirolt K, Plebani A, E PD, Pollok K, Pommerening H, Popihn D, Poplonek A, Popp M, Porta F, Portegys J, Posfay-Barbe K, Potjewijd J, Poulheim S, Prader S, Prämassing-Scherzer P, Prelog M, Prevot J, Price A, Price T, Proesmans M, Provot J, Quinti I, Raab A, Rack A, Raffac S, Ramos Oviedo E, Randrianomenjanahary P, Ranohavimparany A, Raptaki M, Rashidzadeh R, Rathwallner M, Reda S, Redouane N, S RF, Reichenbach J, Reimers B, Reinhardt C, Reinhardt D, Reinprecht A, Reisli I, Reiß T, Renner E, Rezaei N, Richter A, Richter D, Rieber Nikolaus P, Rieckehr N, Riedel M, Riescher H, Rischewski J, Ristl N, Ritterbusch H, Ritz T, Rivier F, K RJ, Roesler J, Rofiah H, Rogerson E, Rolfes E, Roller B, Romanyshyn Y, Rondelli R, Roosens F, Rösen-Wolff A, Rösler V, Roth J, Rothoeft T, Roubertie A, Rübsam G, Rusch S, Rutgers A, Ryan P, Sach G, Sadeghi K, Sahrbacher U, Saidi A, Sanal Tezcan Ö, Sanchez-Ramon S, Santos Juan L, Sargur R, Savchak I, Savic S, Schaaf B, Schaefer M, Schäfe C, Scharbatke E, Schatorje E, Schauer U, Scheibenbogen C, Scheible R, Scheinecker C, Schiller R, Schilling B, Schilling F, Schlieben S, Schmalbach T, Schmalzing Marc T, Schmid P, Schmidt N, Schmidt Reinhold E, Schmitz M, Schneider D, T SD, Schneppenheim R, Scholtes C, E H S, Schönberger S, Schreiber S, Schrijvers R, Schroll A, Schruhl S, Schrum J, Schubert R, Schuh S, Schulz A, Schulz C, Schulze I, Schulze-Koops H, Schulze-Sturm U, Schumacher EM, Schürmann E, Schürmann G, Schuster V, Schütz C, Schwaneck E, Schwarz K, Schwarz T, Schwarze-Zander C, Schweigerer L, Schwinger W, Sediva A, Seebach J, Seger R, Segerer F, Selle B, Seneviratne S, Seny Gueye M, Shabanaj H, Sharapova S, Shcherbina A, Shillitoe B, Siepelmeyer A, Siepermann K, Simon A, Simon A, Simon-Klingenstein K, Simonovic M, Sitkauskiene B, Skapenko A, Skarke M, Skomska-Pawliszak M, Slatter M, Smet J, Smith C I E, Sobh A, Sobik B, Sogkas G, Sohm M, Solanich-Moreno X, Soler Palacín P, Sollinger F, Somech R, Sonnenschein A, Soresina A, Sornsakrin M, Soura S, Spaccarotella S, Spadaro G, Sparber-Sauer M, Specker C, Speckmann C, Speidel L, Speletas M, Stachel KD, Stanislas A, Stapornwongkul C, Staus P, Steck R, Steele C, Steffin H, Steiner U, Steinmann S, Stevens W, Stiefel M, Stieger S, Stiehler S, Stimm H, Stojanov S, Stoll M, Stoppa-Lyonnet D, Strapatsas T, Strauß G, Streiter M, Strik-Albers R, Strotmann G, Suárez Casado H, Subiza Jose L, Sundin M, Süß B, Sutter F, Szaflarska A, Szemkus M, Tamary H, Tantou S, D TM, Taschner H, Taucher S, Tedgard U, Teixeira C, Rjm TB, Tenbrock K, Tester S, Tezcan I, Thalguter S, Thalhammer J, Thoma K, Thomas M, Thomczyk F, Thon V, Thrasher A, Tierney P, Tietsch N, Tomic M, Tommasini A, Tönnes B, Tony HP, Trachana M, Trapp C, Tricas L, Trindade Neves Maria C, Trischler J, Ubieto H, Uelzen A, Uhlmann A, Ullrich J, Ullrich K, Ünal E, Urbanski G, Urschel S, Uszynska A, Vacca A, N N V, Vagedes D, Valicevic S, Vallelian F, van Beem Rachel T, van Damme C, van de Ven A, van den Berg J M, van der Flier M, van Dissel JT, van Hagen PM, van Montfrans JM, van Ogtrop G, van Rens J, van Riel Christel AMP, van Royen-Kerkhof A, van Well G TJ, Vasiliki A, Velbri S, Vencken J, Ventura A, Vermeulen F, Vermylen C, Viemann D, Viereck A, Villa A, Vincke J, Vinnemeier-Laubenthal L, Vo TKD, Vollbach K, Volokha A, von Bernuth H, von Bismarck P, Voss R, Voß S, Vural Y, Wachuga H, Wagner N, Wagström P, Wahle M, Wahn V, Wapp N, Warnatz K, Warneke M, Warris A, Wasmuth JC, Wasserfallen JB, Wawer A, Weber M, M R WC, Weidinger S, Weiß M, Weißbarth-Riedel E, Werner A, Wessel S, Westkemper M, Wicher M, Wickmann L, Wiegert S, Wiehe M, Wiehler K, Wiesböck L, Wiesik-Szewczyk E, Williams A, Winkler B, Winkler C, Winkler M, Winkler M, Wintergerst U, Wisgrill L, de Witte J, Witte T, Wittkowski H, Wolf B, Wölke S, Wolschner C, Wolska-Kusnierz B, Wood P, Workman S, Worth A, Wortmann M, Wuillemin Walter A, M WN, Wustrau K, Wyndham-Thomas C, Yegin O, Yildiran A, Yilmaz D, Young P, Yucel E, Zečević M, Erić Ž, Zepp F, Zetzsche K, Zeuner R, Zielen S, Zimmermann M
KeywordsCOVID‐19, SARS‐CoV‐2, agammaglobulinemia, intravenous immunoglobulin, neutralizing antibodies, primary immunodeficiency
Read Read publication