Epidemiology of supplemental oxygen in patients with pulmonary hypertension.
Background and objective
Patients with pulmonary hypertension (PH) may present with hypoxaemia at rest or during daily activities. There is no epidemiological data on the prescription of long-term oxygen therapy (LTOT) in patients with PH. The study sought to analyse the prevalence and incidence of LTOT prescription among patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) in Spain and to determine predictors for this prescription.
Methods
A retrospective analysis was performed from the Spanish Registry of Pulmonary Arterial Hypertension (REHAP). Collected data included demographics and anthropometric measurements, functional class (FC), arterial blood gases, pulmonary function tests, haemodynamic measurements, six-minute walking distance (6MWD) and LTOT prescription. In addition, we assessed the prevalence and incidence of LTOT prescription by PH group and subtype and potential predictors for LTOT initiation in the first 5 years after diagnosis.
Results
We analysed 4533 patients (69.9% PAH and 30.1% CTEPH), mostly female (64.5%), with a mean age of 53.0 ± 18.3 years. The prevalence of LTOT was 19.3% for all patients. The incidence of LTOT prescriptions decreased from 5.6% to 1.6% between 2010 and 2019, respectively. Predictors for LTOT prescription, excluding those that represent the indication for oxygen therapy were: FC (HR: 1.813), 6MWD (HR: 1.002), mean pulmonary arterial pressure (mPAP) (HR: 1.014), cardiac index (CI) (HR: 1.253), pulmonary vascular resistance (PVR) (HR: 1.023) and diffusing capacity of carbon monoxide (DLCO) (HR: 1.294).
Conclusion
The prevalence of LTOT in PAH and CTEPH patients is close to 20%. FC, 6MWD, mPAP, CI, PVR and DLCO were predictors for LTOT prescription.
© 2024 Asian Pacific Society of Respirology.
Overview publication
| Title | Epidemiology of supplemental oxygen in patients with pulmonary hypertension. |
| Date | 2025-01-01 |
| Issue name | Respirology (Carlton, Vic.) |
| Issue number | v30.1:70-79 |
| DOI | 10.1111/resp.14821 |
| PubMed | 39210654 |
| Authors | |
| Info | REHAP Investigators, Álvarez Barredo M, Angullo Gómez M, Aurtenetxe Pérez A, Barbera JA, Becerra Muñoz VM, Bedate P, Blanco I, Bravo Marqués R, Cadenas Menéndez S, Callejas Rubio JL, Carmona Segovia AM, Carrillo J, Casado Moreno I, Castejón Pina N, Castro M, Chamorro Fernández CI, Cifrián JM, Clavero Sánchez T, Crémer Luengos D, Del Prado Díaz S, Dobarro D, Domingo Morera JA, Elías Hernández T, Escribano Subías P, García Flores PI, García Hernández FJ, Gonçalves Dos Santos Carvalho F, González Segovia A, Guerra Ramos FJ, Hermida T, Hinojosa W, Jaimes Diaz SV, Jara Palomares L, Jiménez Arjona J, Lacuey Lecumberri G, Lara Padrón A, Lázaro Salvador M, López-Meseguer M, López Reyes R, Luna López R, Marín González M, Márquez Moreno JM, Martínez García F, Martínez Meñaca A, Melendo Viu M, Melero Ferrer J, Mombiela T, Mora Cuesta VM, Naranjo Velasco V, Noris Mora M, Núñez Ares A, Ochoa Parra N, Otero Candelera R, Otero González I, Pastor Pérez F, Pérez Peñate GM, Pérez Sagredo J, Pérez L, Ramírez Martín P, Ramón Capilla M, Recio Mayoral A, Rey Chacón I, Ribas Sola J, Rodríguez Chiaradía DA, Rodríguez Penas D, Rueda Soriano J, Sáez Giménez B, Safont B, Sala Llinas E, Segovia Cubero J, Sintes Permanyer H, Soto Abánades C, Suberviola V, Tenes JA, Torrents Vilar A, Torres-Castro R |
| Keywords | chronic thromboembolic pulmonary hypertension, incidence, long‐term oxygen therapy, prevalence, pulmonary arterial hypertension |
| Read | Read publication |