Prognostic significance of electrophysiological study in drug-induced type-1 Brugada syndrome: a brief systematic review.

Background

Risk stratification in drug-induced type-1 Brugada syndrome (BrS) patients is challenging. The role of electrophysiological study (EPS) is debated as the majority of drug-induced type-1 BrS patients would not be studied according to the latest recommendations.

Methods

A complete systematic literature search was performed to gauge the EPS role in this population. Three subgroups were defined: positive-EPS group, negative-EPS group, no-EPS group.

Results

Among 1318 drug-induced type-1 BrS patients, no significant difference in the incidence rate of arrhythmic events was observed between groups (I2 = 45%, P for subgroup difference = 0.10) during a mean follow-up of 5.1 years, also considering symptomatic status.

Conclusion

In long-term follow-up of drug-induced type-1 BrS patients, EPS does not seem to aid prognostic stratification.

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