Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity.
The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.
© 2025. The Author(s).
Overview publication
| Title | Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity. |
| Date | 2025-01-09 |
| Issue name | Communications biology |
| Issue number | v8.1:33 |
| DOI | 10.1038/s42003-024-07314-y |
| PubMed | 39789223 |
| Authors | |
| Info | Scourge Cohort Group, Abellán J, Acosta-Isaac R, Aguado JM, Aguilar C, Aguilera-Albesa S, Sabbagh AA, Alba J, Albu S, Alcalá-Gallardo KAM, Alcoba-Florez J, Batres SA, Algarin-Lara HR, Almadana V, Medeiros KA, Almeida J, Almoguera B, Alonso MR, Álvarez N, Álvarez-Sala Walther R, Álvarez-Benítez Y, Álvarez-Navia F, Dos Santos KA, Andreu-Bernabeu Á, Antonijoan MR, Martínez-Aquino E, Arana-Arri E, Aranda C, Arango C, Araque C, Araujo NK, Arcanjo AC, Arnaiz A, Arnalich Fernández F, Arranz MJ, Arribas López JR, Artiga MJ, Avello-Malaver Y, Ayuso C, Ballina Martín B, Baptista-Rosas RC, Baldion AM, Barranco-Díaz A, Barreda-Sánchez M, Barrera-Penagos V, Belhassen-Garcia M, Bernal-Bello D, Bernal E, Bezerra JF, Bezerra MAC, Blanca-López N, Blancas R, Boix-Palop L, Borobia A, Bravo E, Brion M, Brochado-Kith Ó, Brugada R, Bustos M, Cabello A, Cáceres A, Cáceres-Agra JJ, Calbo E, Calderón EJ, Camacho S, Ceballos FC, Cañadas Y, Carbonell C, Cardona-Huerta S, Sánchez-Carpintero Abad M, Carpio-Segura C, Carrillo-Avila JA, Campos MC, Casasnovas C, Castaño L, Castaño CF, Castelao JE, Candalija AC, Castillo MA, Chaves-Santiago WG, Chiquillo-Gómez S, Cid-López MA, Cienfuegos-Jiménez Ó, Conde-Vicente R, Cunha GCR, Cordero-Lorenzana ML, Corella D, Corrales A, Cortés-Sánchez JL, Corton M, Souza KSC, Silva FTC, Cruz R, Cuesta L, Tavares NAC, Carvalho MCC, Dalmau D, Dantas-Komatsu RCS, Darnaude MT, de Andrés R, de Juan C, de la Cruz Troca JJ, de la Horra C, de la Hoz AB, De Martino-Rodríguez A, Cruz MS, de Sousa Alves Neri JL, Del Campo-Pérez V, Delgado-Cuesta J, de Bustamante AD, Díaz-Pérez A, Dietl B, Diz-de Almeida S, Alves MDM, Domínguez-Garrido E, Rosa LS, Luchessi AD, Echave-Sustaeta J, Eiros R, Enciso-Olivera CO, Escudero G, España PP, Sanabria GE, Carmen Fariñas M, Fernández R, Fernández-Caballero L, Fernández-Cruz A, Fernández-Ferrero S, Fernández Martínez Y, Fernandez-Nestosa MJ, Fernández-Robelo U, Fernández-Rodríguez A, Fernández-Sampedro M, Fernández R, Fernández-Villa T, Fernández-Capitán C, Carioca AAF, Flores-Pérez P, Fuenmayor-Hernández L, Fuertes-Núñez M, Fumadó V, Gadea I, Gagliardi L, Gago-Domínguez M, Gallego N, Galoppo C, García-Soidán A, García-Cerrada C, García-de-Vicuña A, Garcia-García J, García-García I, García-Ibarbia C, García-Montero AC, García L, García M, García Torrejón MC, García I, García-Vázquez E, Garza-Frias E, Gentile A, Gil-Fournier B, de Araújo JNG, Gómez-Duque M, Gómez-Arrue J, Gómez Carrera L, Gómez García M, Gómez Sacristán Á, González JR, González-Neira A, González Álvarez B, González Bernaldo de Quirós F, González-Montelongo R, González-Peñas J, Gonzalez-Sagrado M, Gonzalo-Benito H, Gorgojo-Galindo O, Górgolas M, Guaragna F, Chaux JG, Guillén-Navarro E, Guillén-Guío B, Guisado-Vasco P, Gutiérrez-Castañeda LD, Gutiérrez-Bautista JF, Heili-Frades S, Jacomo RH, Hernández E, Hernández-Moro C, Hernández-Ortega LD, Hernández-Pérez G, Hernández-Vaquero R, Herráez B, Herranz MT, Herrera M, Herrero MJ, Herrero-González A, Horcajada JP, Imaz-Ayo N, Intxausti-Urrutibeaskoa M, Íñigo-Campos A, Íñiguez M, Jara R, Jiménez Á, Jiménez P, Jiménez-Sousa MA, Jordan I, Jiménez-Alfaro I, Laguna-Goya R, Laorden D, Lasa-Lázaro M, Lattig MC, Lauriente A, Borja AL, Llanos L, López-Bernús A, López de Heredia M, Lopez-Garcia E, López-Granados E, Lopez-Rodriguez R, López-Ruz MA, Lorente L, Lorenzo-Salazar JM, Lozano JE, Lozano-Espinosa M, Mahillo I, Mancebo E, Mar C, Calvo CM, Marcos-Delgado A, Marcos M, Marín-Candón A, Mariscal-Aguilar P, Martin-Pedraza L, Martin-Fernandez M, Martín-López C, Martín-Oterino JÁ, Martín MD, Martín V, Martín MM, Martín-Vicente M, Martinez A, Martínez-González Ó, Martínez R, Martinez-Paz P, Díaz-Caneja CM, Martínez-Nieto Ó, Martínez-López I, Martínez-Reséndez MF, Martínez S, Martínez JJ, Martínez-Pérez Á, Martínez-Ramas A, Martínez-Robles V, Marzal L, Mazzeu JF, Medrano FJ, Meijome XM, Mejuto-Montero N, Mendes I, Duarte AL, Méndez-Echevarría A, Charris HM, Merayo Macías E, Mercadillo F, Mercado-Sesma AR, Mínguez P, Molina-Roldán E, Molina AJJ, Montoya JJ, Pinho SMT, Moreira-Escriche P, Morelos-Arnedo X, Moreno R, Moreno Cuerda V, Moreno-Docón A, Moreno-Escalante J, Moreno Fernández A, García PM, Neira P, Nevado J, Nieto-Gañán I, Silbiger VN, Nuñez-Torres R, Obrador-Hevia A, Ocejo-Vinyals JG, Olivar V, Oliveira SF, Ondo L, Orfao A, Ortega-Paino E, Ortega L, Ortiz-López R, Ortiz-Flores F, Oteo JA, Pacheco M, Pacheco-Miranda FJ, Padilla-Conejo I, Panadero-Fajardo S, Parellada M, Pariente-Rodríguez R, Friaza V, Paz-Artal E, Peces-Barba G, Pedromingo Kus MS, Perales C, Santos NPC, Guegel GP, Jazmín Pérez M, Pérez A, Pérez-Matute P, Pérez C, Pérez-de-Nanclares G, Pérez-García F, Pérez P, Pérez-Jurado LA, Pérez-Tomás ME, Perucho T, Pichardo LA, Ribeiro AP, Pinsach-Abuin ML, Pinzón LA, Medeiros JFP, Pita G, Pla-Juncà F, Planas-Serra L, Pompa-Mera EN, Porras-Hurtado GL, Pujol A, Quevedo-Chávez ME, Quijada MA, Quintela I, Ramiro-León S, Sedes PR, Nunes JFR, Recalde D, Recio-Fernández E, Resino S, Sousa RR, Rivadeneira-Chamorro CS, Roa-Agudelo D, Pardo MR, Fernandes MR, Rodríguez-Hernández MA, Rodriguez-Palmero A, Rodríguez-Ruiz E, Rodriguez MJ, Rodríguez-Artalejo F, Rodríguez-Ferrer M, Rodríguez-Gallego C, Rodríguez-García JA, Rodríguez Maya B, Rodriguez-Nicolas A, Rodríguez-Novoa GE, Rodriguez-Urrego PA, Rojo F, Romero-Coronado A, Morilla R, Rondón-García F, Rosales-Castillo A, Rubio C, Rubio Olivera M, Ruiz-Cabello F, Ruiz-Casares E, Ruiz-Cubillan JJ, Ruiz-Hornillos J, Ruiz M, Ryan P, Salamanca HD, Salazar-García L, Salgueiro-Origlia GG, Sangil A, Sánchez-Pernaute O, Sánchez PL, Sánchez López AJ, Sánchez-Pablo C, Sánchez-Prados MC, Sánchez-Real J, Sánchez-Redondo J, Sancho-Sainz C, Sande E, Santos A, Schlüter A, Segovia S, Serra-Llovich A, Sevil-Puras F, Sevilla-Porras M, Sicolo MA, Silván-Fuentes C, Moraes VMS, Souza VS, Solé-Violán J, Soria JM, Sorlí JV, Silva NS, Souto JC, Sprockel JJ, Suárez-Rama JJ, Suárez-Zamora DA, Taboada-Fraga X, Tamayo E, Tamayo-Velasco A, Taracido-Fernández JC, Vasconcelos RHT, Tellería C, Carratto TMT, Tenorio-Castaño JA, Teper A, Araujo IMT, Torres-Macho J, Torres-Tobar L, Torres-Gutiérrez RP, Troya J, Urioste M, Valencia-Ramos J, Valido A, Vargas-Gallo JP, Varón B, Vega T, Velasco-Quirce S, Vélez-Santamaría V, Víctor V, Vidán-Estévez J, Silva GV, Vieitez-Santiago M, Vilches C, Villalobos L, Villar F, Villar-Garcia J, Villaverde C, Villoslada-Blanco P, Virseda-Berdices A, Costa TX, Yáñez Z, Zapatero-Gaviria A, Zarate R, Zazo S, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P, Carracedo Á |
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