Auditory evoked delta brushes involve stimulus-specific cortical networks in preterm infants.

During the third trimester of gestation in humans, the auditory cortex displays spontaneous and auditory-evoked EEG patterns of intermittent local oscillatory activity nested in delta waves - delta brushes (DBs). To test whether the spatiotemporal dynamics of evoked DBs depends on stimulus type, we studied auditory evoked responses (AERs) to voice and "click" using 32-electrode EEG in 30 healthy neonates aged 30 to 38 post-menstrual weeks. Both stimuli elicited two peaks at approximately 250 ms and 600 ms, the second corresponding to the first principal components of the AER and the evoked DB. The DB showed stimulus-specific topography, temporal posterior and mid-temporal for "click", and mid-temporal and pre-central inferior for voice, and contained theta to gamma oscillations more widespread for the "click"response. Gamma oscillations increased with age. AERs predominated on the right but shifted toward the left with age for voice response. Auditory evoked DBs may therefore underlie specific auditory processing during fetal development.

© 2025 The Authors.